Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. My Collie is double MDR1 mutant. He was getting quite stiff and sore, but he acts like a much younger dog now. We need more people like you. Simparica Trio is an all-in-one monthly chewable treatment for dogs. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. However, it did make my Collies too itchy. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Congratulations on your new puppy. for, I think its brown ticks. I know it contains Ivermectin, so I am not sure this information is correct. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. . After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Safety has not been evaluated in pregnant, breeding or lactating dogs. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Could that have been the cause of the seizure, even though she took it more than a month ago? With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. I would appreciate your comments on Advocate. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. In FL resistance is bad, and we split our time between FL & NJ. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Mar 2013. Additionally, it can be used to treat and control sarcoptic mange. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . I also have Aussies and have always been very careful about what I give them. Im just looking for advice as to tick prevention medication. It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. The drawback of Advantage is that it does not offer any protection against ticks. Apparently, it affects certain cats with a certain gene. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Unacceptable for me) He is MDR1 clear. The oral chew contains a specially optimised trio of ingredients for . The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. It was the amount of ticks Ive been having to remove that lead me to your article! I doubt it as he was on leash and Im always watching him. Opioid pain relievers are essential drugs, and appear safe if used with care. Freckles my Aussie/Pyr is such a great dog. The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Hi Debbie! Simparica trio prescribed to 10 wk aussie pup. Just want to do what is best for them? I will try to find the article again, I stupidly didnt bookmark it. They both have tolerated Bravecto very well.no noticeable side effects. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? THREE OF THE 8 FEMALES WENT INTO ESTRUS. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. This May he tested positive again, but the vet thinks it could be residual from when he had it before. Thank you for the warning. She is just 1 year old. And safe travels to you and Lola in the future. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Ive changed the label on the Seresto section and added some info to keep it current. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. I tried Seresto with my girl and she had a seizure. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. Thank you for this thorough and thoughtful work, Emily! If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. He had been taking the it for about 2-3 months. Use of those drugs can cause serious neurological illness or death. Whats the best safest flea tick treatment for a collie puppy? Rev. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. We have a almost 10 year old tricolor rough collie, named Hollie. Thank you, and hello to Nola and Otis! Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. Thank you for the reminder! Happy to be of help! Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. (One such knockoff, Pet Armor Plus, is even available at Walmart.). It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Thank you. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. It provides 100% protection from heartworm disease. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Im leaning toward Frontline Plus based on what you wrote. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Simparica TRIO requires a prescription from your veterinarian. Appreciated!!! I just quote the ones who are knowledgeable about MDR1. Eliminate fleas before they lay eggs. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. Should I give them Trifexis or Sentinel Spectrum? However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. Hi! I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. ivermectin, selamectin)? Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis 2. collies. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. I follow this advice, since Im a safe-is-better-than-sorry person. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. We will get her in about 3 weeks. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. The main goal of this medication, according to the FDA, is; The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Tap to zoom. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. Hope this helps! The FDA noted that these products continue to be safe and effective for the majority of animals. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. Dogs, 6 Month Supply removed from the wishlist. (Which made him feel really sick.) Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Simparica. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. (I have to give them baths with a very mild or medicated shampoo.) However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. A similar medication, Comfortis (spinosad), only treats external parasites. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Sugar is a great name for a Collie as they really are such sweethearts. Best of luck! Its worth making a phone call to see what they would recommend for your pup. I appreciate the research in this thank you! Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Is credelio considered safe when using interceptor? Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. I am going to try WonderCide as recommended by my Vet for fleas. I appreciate your help as I was trying to navigate so much conflicting information!! I didnt see the link for the drug compatibility. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. But of course, do talk to your vet and see what they know. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. GestorVet es el futuro de la gestin veterinaria. How to use Simparica Trio. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. . (Same active ingredients in both.) While my pain levels went down, I noticed that my heart rate went up! It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. $161.99. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Where can I get them tested for MDR1 resistance. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. 1x 20mg tablet for 11.1 to 22 pounds. You should still keep an eye on your pet when introducing new organic products. Good luck with everything, and please keep me updated on how your pup is doing! For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Theyre both derived from essential oils and smell great, which is a nice bonus. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. Thank you for your article. It covers fleas, ticks, and heart worms. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Interceptor is also available online from pet supply stores such as Chewy. Thanks. Simparica Trio is proven to kill 5 species of ticks. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. . It is also used off-label to control sarcoptic mange and demodectic mange. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. The majority of canines will be fine, but there are enough who will react. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Thank you so much for writing this article and for the information you provided. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Simparica Trio is a powerful oral treatment that provides triple protection. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. This is so thorough and helpful! Personally, I would be concerned about missing a daily dose. Please tell me if I am wrong. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Thank you for such a great article! However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. Super useful research. I gave a mini aussie and a minnie aussie/border collie mix. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! So, I now need a good flea/tick med and would rather not get another pill for her to take. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. You might want to look at the information on Nexgard. On the down side, it does not cover any ticks. Im happy to hear you found it helpful! So we started her back on Sentinel earlier this year, she really had stomach issues. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; My 2 Collies both had negative skin reactions to Advecta 3D, unfortunately. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. Components Species Test Results Silica colloidal, Ph. I had never heard of Dimmitrol before, but I did some research after reading your comment. Matching game, word search puzzle, and hangman also available. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. And thank you for saying so. The flavored, chewable tablets were consumed . However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Will you be updating this article with regard to Seresto? Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Nothing could be done for them. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. I like Frank so much that I had to give him his own story. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Seven Collies sound like a lot of work but also very wonderful! I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. For the majority of dogs, Advecta is probably fine! Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. I just had my vet mention the mdr1 gene today in passing. This article (authored by two veterinarians) is an excellent resource for more professional information. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. That age, what about the use of Simperica Trio for a Collie your article has been very helpful my! Heard of Dimmitrol before, but it really depends on the dog might also,... Your border Collie females with sarcoptic mange consultations with our primary care vet, we took him off.... 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